Hepatic lipidosis

Hepatic lipidosis, also known as fatty liver disease, is characterized by the excess accumulation of fat in the liver. It is usually the end-point of untreated GI stasis. :312 Once hepatic lipidosis is established, fatty infiltration of the kidneys occurs and the rabbit goes into liver and kidney failure. :314

Causes
Hepatic lipidosis occurs most readily in obese rabbits because they have already accumulated triglycerides in the hepatocytes and in rabbits fed a high-fat diet. :313 Any rabbit that causes prolonged anorexia can result in fatty infiltration of the liver. :313 Pregnant and lactating rabbits also have an increased risk of developing hepatic lipidosis. :314

Treatment
Hepatic lipidosis can be prevented in anorexic rabbits by maintaining a positive energy balance with nutritional support and prompt treatment.