Sebaceous adenitis

Sebaceous adenitis is an uncommon skin condition in rabbits. It is characterized by flaky dry skin that forms brittle plaques and also by patchy hair loss. Alternative diagnoses might include ringworm (Tinea spp.) and other fungal skin infections, bacterial skin infections, ear mites (Psoroptes cuniculi) and other arthropod infestations. Usually these can be ruled out with skin scrapings and applications of appropriate remedies. Thymoma and leukemia are also known to cause symptoms consistent with sebaceous adenitis. Thymoma can be ruled out by a simple thoracic radiograph. The hallmark of idiopathic sebaceous adenitis (ISA) is histological. A skin biopsy would show sebaceous glands invaded by lymphocytes (if they have not been destroyed already), hyperkeratosis and perifollicular lymphocytic folliculitis in the absence of tumor or cancer.

Typically, rabbits with ISA present with flaky skin and patchy hair loss around the head and shoulders. This is often, but not always, progressive. In some cases these rabbits show neurological involvement and develop an unusual gait that suggests stiffening of [especially of hind end] joints, but may result from muscular ataxia. The condition is sometimes merely uncomfortable for rabbits in early stages, but can be quite painful as the disease progresses.

ISA is thought to be caused by an accumulation of a metabolic intermediate caused by a defect in lipid metabolism in the sebaceous glands and autoimmune response to that accumulated lipid intermediate. The prognosis is generally grim though some success has been seen treating rabbits with cyclosporin A in a medium-chain triglyceride vehicle (Mygliol) orally combined with topical treatment with phosphosphingosine (regular baths and spot treatments). Refined coconut oil is thought to be a topical palliative in lieu of pharmaceutical approach, though many phosphosphingosine sprays, shampoos and conditioners are also available without a prescription. Topical treatments (combination of spray, shampoo and conditioner) usually cost about $60 for a 2 month supply while cyclosporin and Mygliol is much more expensive at about $150 for a 30 day supply.

The causes are not known, though it is plausible that both environmental and genetic causes play a role in the disease. The disease may disproportionately affect female rabbits, though the information supporting this is largely anecdotal.

Successful treatment of idiopathic sebaceous adenitis in a lionhead rabbit (2012) Kovalik, et al.

Successful treatment of sebaceous adenitis in a rabbit with ciclosporin and triglycerides (2009) Lee,  et al.