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Coccidiosis is a disease of animals kept under crowded conditions and caused by a protozoan parasite, Eimeria spp. Intensive, damp, and dirty conditions such as many breeding establishments predispose to coccidiosis.[1]

About the parasite

Coccidia strains are highly host- and site-specific, and infection occurs by ingestion of oocysts passed in the feces of infected rabbits. The oocysts require 48 to 70 hours outside the host to produce spores, are very resistant in the environment, and can survive for years. They can be spread through feed, soil, and any other substance that is capable of carrying infectious organisms (e.g. blankets, clothing, skin).

Ingestion of the oocyst releases sporozoites into the small intestine after the oocyst have been broken down by digestive enzymes. The sporozoites invade cells and cause tissue damage as they complete their complex life cycle.

As many as 14 species of Eimeria have been described in the rabbit. All but one species are found in the small intestine, cecum, or colon and cause intestinal coccidiosis. The species Eimeria stiedae inhabites the liver and causes hepatic coccidiosis.

There is no cross-immunity between the different species of Eimeria.[1]


The disease is often asymptomatic, but signs of the parasite include the following:

  • Watery-to-mucoid, sometimes blood-tinged, diarrhea. The diarrhea may be intermittent.
  • Weakness, lethargy, dehydration, and weight loss with heavy infections, especially in young rabbits.
  • Can cause the inversion of the intestine (intussusception) and even death.
  • With hepatic (liver) involvement, may see anorexia, weight loss (cachexia), depression, abdominal enlargement and pain, diarrhea, or acute death.


  • Infected rabbits contaminating the environment.
  • Poor sanitation.

Stress, debility, and concurrent disease can predispose older animals to infection.


Diagnosis for coccidiosis is done by fecal flotation by identifying the oocysts in the feces or under the microscope by counting the coccidia per gram of feces.


Anti-coccidiosis treatment is successful only for rabbits infected since 5 to 6 days.[2]

Current effective choices for medication include the following:

  • sulphadimethoxine in drinking water - most effective[2]
  • sulphaquinoxaline in drinking water
  • sulphadimerazine in drinking water
  • salinomycine (Bio-Cox)
  • diclazuril (Clinicox)
  • toltrazuril (Baycox)

The above treatments should be given to all rabbits for at least 5 days and repeated after 5 days.

Robenidine hydrochloride is also well tolerated by rabbits, but its preventative use over the past 20 years have raise the resistance of the protozoa to the drug.

The environment should also be regularly cleaned and disinfected with ammonia to prevent reinfection.


The following are some experiences of bunny owners with coccidia.

Further reading

See also


  1. 1.0 1.1 Varga, M. (2013). Textbook of rabbit medicine. (2nd ed.).
  2. 2.0 2.1 Praag, EP. (n.d.). Protozoal enteritis: Coccidiosis. Retrieved 19 Dec 2019 from