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The curse of the 33 spots...

"A change in breeders' attitude and breeding practices is mandatory because neither the permanent elimination of animals not "fitting" a fancy standard nor the continuous production of defective genotypes is legal." - Gerlitz S., Wessel G., Wieberneit D., & Wegner W.

Megacolon is a genetic condition that is usually caused by the KIT gene. Megacolon is also known as congenital agangliosis or cow pile syndrome (CPS).


Common symptoms of rabbits exhibiting megacolon include the following:

  • Big misshapen soft fecal pellets, frequently covered with mucus.
  • Common bouts of GI stasis. During incidents, it may be possible to feel large masses of fecal material similar in consistency to ropes of play dough.
  • Unable to produce cecotropes.
  • Difficulty maintaining weight.

Megacolon often comes in episodes, characterized by flare-ups in between periods of relative improvement.


Megacolon usually comes into play when a rabbit inherits two of the dominant versions of the "English spotting gene" (En/En), also called charlies. There are three options possible when inheriting the spotting genes. The latest genetic study, from the University of Bologna in Italy, shows that if a rabbit inherits a recessive and dominant (En/en - normal amount of spots) or two recessive (en/en - solid color, no spots) English spotting genes they will not have megacolon. Only rabbits that inherit two of the dominant versions of the "English spotting gene" (En/En - very lightly spotted rabbit) can be affected by megacolon.

During early cell migration early in the rabbit's embryonic development the KIT gene expresses itself resulting in potential problems. KIT controls some cell processes such as cell division and cell movement (migration). This includes the development of cells in the GI tract and cells called melanocytes (melanin). This results in a large reduction of cells to the rabbit's outer muscle wall in the GI tract (cecum and ascending colon). These pacemaker cells control the rate and strength that the outer muscle wall contracts that help move things along in the affected area. This is also the cause for the reduced number of spots on the rabbit's fur.


At this time there is no conclusive test for the disorder. The diagnosis is presumptive in rabbits where other causes of similar symptoms are ruled out by testing or unsuccessful treatment.


Treatment between rabbits varies greatly due to differences in digestions. Most rabbits with megacolon do not tolerate greens well, but this may not be true for all. Since rabbits with megacolon often need extra nutritional support, eliminating foods may not be a good idea.

Common support tips for rabbits with megacolon include the following:

  • Encourage water consumption and exercise.
  • Stick to a strict feeding routine and schedule. Once you find a diet that works for your rabbit, do not change it unless it stops working.
  • Keep your rabbit's area clean to reduce the number of butt baths needed.
  • Minimize stress and changes.

Further reading

See also