Common drug dosages for rabbits

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Please remember that all information on this wiki is not intended to diagnose or treat your pet. Information presented here is for educational purposes only and not to substitute for a veterinary consultation. This site makes no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the website or the information, or related graphics contained on the website for any purpose.

Dosages on these pages have been compiled from various formulary textbooks and resources with rabbit dosages.

Do not change your rabbit's drug dosage without consulting your rabbit-savvy veterinarian.


BW body weight
IM intramuscular injection
IN intranasal
IP within the abdominal cavity
IV intravenous injection
SC subcutaneous injection
PO per os = orally
h hour
q every
sid once a day
bid twice a day
tid three times a day
qid four times a day
qod every other day

Dosages of common drugs

Bolded drugs with a green background are authorized for use in rabbits.

Drug Name Brands Type Dosage Remarks
Acepromazine ACP Sedative
  • 0.1-1.0 mg/kg IM/SC (Meredith, 2015)
  • 0.5-1 mg/kg IM/SC (Varga, 2013)
  • 0.25-1 mg/kg; SC/IM (Blackwells, 2011)
  • 0.1-1.0 mg/kg IM/SC (Ramsey, 2011)
  • 2 mg/kg BW IM (Bauck, 1989)
  • 5 mg/kg BW IM (Flecknell, 1987)
  • 1-2 mg/kg BW IM (Harkness and Wagner, 1983)
Formulations available:[1]
  • Injectable: 2 mg/ml solution.
  • Oral: 10 mg, 25 mg tablets.

Not analgesic. Should not be used in animals less than 3 months of age or with liver disease.[1]

Acepromazine + butorphanol Sedative
  • 0.5 mg/kg + 0.5 mg/kg IM, SC (Varga, 2013)
Can by mixed in same syringe.


Paracetamol, Pardale V, Perfalgan Analgesic
  • 200-500 mg/kg PO (Ramsey, 2011)
Overdose may cause liver damage.
Acetaminophen-codeine Analgesic
  • 1 ml elixir/100 ml drinking water (Wixson, 1994)
Acetylcysteine Ilube, Parvolex Mucolytic
  • Mucolytic: nebulize 50 mg as 2% (dilute with saline) solution over 30-60 min as required (e.g. q6-12 hours) (Meredith, 2015)
  • Otic lavage: 1-2 ml of a 20% solution (Meredith, 2015)
Formulations available:[1]
  • Injectable: 200 mg/ml solution
  • Topical: 5% ophthalmic solution in combination with 0.35% hypromellose ophthalmic drops in 10 ml bottle

Used as a mucolytic in respiratory disease. In rabbits, direct application into ear has been reported as beneficial in cases of secretory otitis media, reducing inflammation and preventing long-term fibrotic changes.[1]

Activated charcoal Antidote
  • 0.5-5 g/kg PO (anecdotal) (Meredith, 2015)
  • 1-3 g/kg every 4-6 hours as needed PO. Dilute 1 g charcoal/5-10 mL water. (Blackwells, 2011)
Formulations available:[1]
  • Oral: 50 g activated charcoal powder or premixed slurry (200 mg/ml).

Absorbs toxins, fluids, and gases in the GI tract. As a general rule, administer at a dose of at least 10 times the volume of intoxicant ingested.[1]

Activated charcoal flats, covering everything in the area — use carefully as it will stain permanently. May color stools black, which can be alarming to owners. Will reduce efficacy of orally administered drugs.[1]

Adrenaline, Epinephrine Vasopressor,
Adrenergic bronchodilator
  • Cardiac resuscitation: 100 µg/kg IV, repeated and/or higher doses (up to 200 µg/kg) may be required at intervals of 2-5 min.
Formulations available:[1]
  • Injectable: 0.1-10 mg/ml, equivalent to 1:10,000 to 1:100.

Used for cardiac resuscitation, status asthmaticus and to offset the effects of histamine release in severe anaphylactoid reactions.[1]

Adrenaline is sensitive to light and air; do not use if pink, brown, or contains a precipitate.[1]

Aglepristone Alizin Antiprogestin
  • Pregnancy termination: 10 mg/kg on days 6 and 7 post implantation
Formulations available:[1]
  • Injectable: 30 mg/ml solution.

Used to terminate pregnancies.

Use with care. Accidental injection may be a hazard to women who are pregnant or intending to become pregnant.[1]

Albendazole Antiparasitic
  • 20 mg/kg PO daily for 3-14 days (Varga, 2013)
  • 20-30 mg/kg once daily; PO for 30 days, then reduce to 15 mg/kg once daily PO for 30 days (Blackwells, 2011)
Used treat Encephalitozoon cuniculi.
Alfaxan-CD Sedative
  • Unpremedicated: 1-3 mg/kg IV or 3-6 mg/kg IM (Meredith, 2015)
  • 6-9 mg/kg IV or 9 mg/kg IM (Ramsey, 2011)
Formulations available:[1]
  • Injectable: 10 mg/ml solution.
Does not contain an antimicrobial preservative, so it is recommended to discard the remainder of an opened bottle after single use within 24 hours.[1]
Alphaxalone-alphadolone Sedative
  • 9-12 mg/kg BW IM (Flecknell, 1987)
Alfentanil Rapifen Analgesic
  • 0.03-0.07 mg/kg IV (Meredith, 2015)
Formulations available:[1]
  • Injectable: 0.5 mg/ml solution, available in 2 ml or 10 ml vials; 5 mg/ml solution

A very potent opioid analgesic - 10-20 times more potent than morphine.[1]

Aluminum antacids,
Aluminum hydroxide
Alucap. With alginate: Acidex, Gastrocote, Gaviscon, Advance, Peptac. With magnesium salt: Asilone, Maalox, Mucogel. Antacid
  • 30-60 mg/kg PO q8-12h (Meredith, 2015)
Formulations available:[1]
  • Oral: available as a dried gel. Other products are composite preparations.

Used for management of gastritis and gastric ulceration. Thoroughly mix drug with food to disperse it throughout the GI tract and increase palatability.[1]

Amantadine Lysovir, Symmetrel Analgesic
  • 3-5 mg/kg PO q24h (Meredith, 2015)
Formulations available:[1]
  • Oral: 100 mg capsule; 10 mg/ml syrup

Proves analgesia through NMDA antagonist action. Used in animals that are unresponsive to opioids or require chronic pain relief in a home environment. May have a role in the treatment of neuropathic pain in rabbits.[1]

Amikacin Amikacin, Amikin Antibiotic
  • 2-10 mg/kg IV/IM/SC q8-12h (Meredith, 2015)
  • 2-5 mg/kg SC/IM bid-tid (Varga, 2013)
  • General antibiotic therapy: 2 mg/kg q8h; SC, IM, IV (Blackwells, 2011)
Formulations available:[1]
  • Injectable: 50 mg/ml, 250 mg/ml solutions.

Active against many gram-negative bacteria such as Staphylococcus aureus and Nocardia spp., including some that may be resistant to gentamicin. Streptococci and anaerobes are usually resistant.[1]

Can affect renal function if hydration not maintained.[1]
Oral doses can cause fatal enterotoxaemia in rabbits.[1]
Aminopyrine Analgesic,
  • 50 mg/kg BW PO (Jenkins, 1987)
Amino acid solutions Duphalyte, Aminoplasmal, Aminoven, Clinimix, Glamin, Hyperamine, Intrafusin, Kabiven, Kabiven Peripheral, Nutriflex Nutritional support
  • Anecdotally, used alone or diluted with LRS at 1:5 ratio and given at a total volume of approx. 100 ml/kg/day. (Meredith, 2015)
Formulations available:[1]
  • Injectable: synthetic crystalline l-amino acid solutions for IV use only. Available in a variety of concentrations.

Amino acid solutions supply essential and non-essential amino acids for protein production. They are used parenterally in patients requiring nutritional support but unable to receive enteral support.[1]

Should not by used for animals with dehydration, hepatic encephalopathy, severe azotaemia, shock, congestive heart failure and electrolyte imbalances.[1]

Amoxinsol, Amoxycare, Amoxypen, Bimoxyl, Clamoxyl, Duphamox, Vetremox Antibiotic
  • 7 mg/kg SC q24h (Meredith, 2015)
Formulations available:[1]
  • Injectable: 150 mg/ml suspension.

Active against certain Gram-positive and Gram-negative aerobic organisms and many obligate anaerobes but not against those that produce penicillinases (beta-lactamases), e.g. Escherichia coli, Staphylococcus aureus. The more difficult Gram-negative organisms (Pseudomonas, Klebsiella) are usually resistant.[1]

Should only be given by injection. Causes diarrhea after oral administration.[2]

Amphotericin B Abelcet, AmBisome, Amphocil, Fungizone Antifungal
  • 1 mg/kg IV q24h (desoxycholate form) or 5 mg/kg SC q24h (liposomal form) (Meredith, 2015)
Formulations available:[1]
  • Injectable: 50 mg/vial powder for reconstitution.

Used for management of systemic fungal infections and leishmaniosis.[1]

Given the risk of severe toxicity it is advisable to reserve use for severe/potentially fatal fungal infections only.[1] Should not be used in animals with renal or hepatic failure.[1]

Medication should be kept in the dark, although loss of drug activity is negligible for at least 8 hours in room light. After initial reconstitution, the drug is stable for 1 week if refrigerated and stored in the dark.[1]

Ampicillin Amfipen, Ampipcaps, Ampicare, Duphacillin Antibiotic DO NOT USE Causes 40 to 100% fatal enteritis, dependent on dosage.[2]

Toxic both orally and parenterally. Bactericidal that is excreted in urine and bile.[3]

Amprolium Coxoid Coccidiostat
  • 20 mg/kg PO q24h for 2-4 weeks (Meredith, 2015)
  • 0.5 mL/500 mL of drinking water for 10 days of 9.6% solution (Blackwells, 2011)
Formulations available:[1]
  • Oral: 3.84% solution for dilution in water.

Used for coccidiosis in animals.

Limit duration of therapy to 2 weeks. Prolonged high doses can cause thiamine deficiency.[1]

Antipyrine Analgesic
  • 500 mg/kg BW PO (Borchard, et al., 1990)
  • 100 mg/kg BW IM/IP/SC (Borchard, et al., 1990)
  • 100 mg/kg BW PO (Jenkins, 1987)
Aspirin Aspirin BP and component of many others Analgesic
  • 100 mg/kg PO q12-24h (Meredith, 2015)
  • 100 mg/kg PO q12-24h (Ramsey, 2011)
  • 20 mg/kg BW PO sid (equivalent to 600-mg dose in humans) (Marangos, et al., 1994)
  • 100 mg/kg BW PO, try q4h (Fleckell, 1991)
  • 400 ml/kg BW SC, PO sid (Harkness and Wagner, 1983)
Formulations available:[1]
  • Oral: 75 mg, 300 mg tablets.

Used to control mild to moderate pain and prevent arterial thromboembolism.

Do not give to dehydrated, hypovolaemic or hypotensive paties or those with GI disease. Do not give to pregnant animals or animals less than 6 weeks old.[1]

Atenolol Atenolol, Tenormin Beta blocker
  • 0.5-2 mg/kg PO q24h (Meredith, 2015)
Formulations available:[1]
  • Oral: 24 mg, 50 mg, 100 mg tablets; 5 mg/ml syrup.

Used for cardiac tachyarrhythmias, hyperthyroidism, hypertrophic cardiomyopathy, obstructive cardiac disease (severe aortic or pulmonic stenosis) and systemic hypertension.[1]

Should not be used for animals with bradyarrhythmias, acute or decompensated congestive heart failure. Relatively contraindicated in animals with medically controlled congestive heart failure.[1]

Atipamezole Alzane, Antisedan, Atipam, Revertor, Sedastop Sedative reversal
  • 2.5 times the previous medetomidine dose. (Meredith, 2015)
Formulations available:[1]
  • Injectable: 5 mg/ml solution

Reverses the sedative effects of medetomidine or dexmedetomidine.

When medetomidine or dexmedetomidine has been administered at least an hour before, dose of atipamezole can be reduced by half (i.e. half the volume of medetomidine or dexmedetomidine) and repeated if recovery is slow.[1]

Atropine Atrocare Premedication
  • 0.04-0.1 mg/kg IM/SC (Meredith, 2015)
  • Organophospate toxicity: 0.05 mg/kg IM (Varga, 2013)
  • Bradycardia: 0.1-0.5 mg/kg; IM, SC (Blackwells, 2011)
  • Organophosphate toxicity: 2-10 mg/kg q20min as necessary; IM, SC (Blackwells, 2011)
  • Mydriasis: 1% atropine ophthalmic drops to dilate eyes in albino animals (Blackwells, 2011)
Formulations available:[1]
  • Injectable: 0.6 mg/ml.
  • Ophthalmic: 0.5%, 1% solution in single-use vials; 5 ml bottle; 1% ointment.

Used to prevent or correct bradycardia and bradyarrhythmias, to dilate pupiles, to manage organophosphate and carbamate toxicities, and in conjunction with anticholinesterase drugs during antagonism of neuromuscular block.[1]

40% rabbits produce atropine esterase that metabolizes atropine.[3] Endogenous atropinase levels may make repeat injections q10–15min necessary.[1]

The solution does not contain any antimicrobial preservative, so any remaining solution in vial should be discarded after use. The solution should be protected from light.[1]

Atropine should not be used in animals with glaucoma, lens luxation, and keratoconjunctivitis sicca.[1]

Atropine +
  • Mydriasis: 1 drop of 1% atropine + 1 drop of 10% phenylephrine ophthalmic drops 3 to 4 times over 15 min to dilate eyes in animals with ocular pigmentation (Blackwells, 2011)
Azithromycin Antibiotic
  • For syphilis: 4-5 mg/kg IM q48h for 7 days (Meredith, 2015)
  • For staphylococcal osteomyelitis: 50 mg/kg PO q24h with 40 mg/kg PO q12 rifamprin (Meredith, 2015)
  • 15-50 mg/kg PO sid (Varga, 2013)
  • Treatment of anaerobic infections: 30 mg/kg PO once daily; can combine with metronidazole 20mg/kg q24h to q12h PO (Blackwells, 2011)
Formulations available:[1]
  • Oral: 250 mg capsule; 200 mg/5 ml suspension (reconstitute with water).

Used for abscesses and osteomyelitis. Alternative to penicillin in allergic individuals as it has a similar, although not identical, antibacterial spectrum.

It is active against Gram-positive cocci (some Staphylococcus species are resistant), Gram-positive bacilli, some Gram-negative bacilli (Haemophilus, Pasteurella), mycobacteria, obligate anaerobes, Chlamydophila, Mycoplasma and Toxoplasma. Some strains of Actinomyces, Nocardia and Rickettsia are also inhibited. Most strains of the Enterobacteriaceae (Pseudomonas, Escherichia coli, Klebsiella) are resistant.[1]

May cause dysbiosis. Should be avoided in animals with renal and hepatic failure.[1]

Barium sulfate Contrast media
  • Gastrointestinal contrast radiography: 10-15 mL/kg; PO (Blackwells, 2011)
Benazepril Benefortin, Cardalis, Fortekor, Nelio, Prilben, Vetpril ACE inhibitor
  • Starting dose 0.05 mg/kg PO q24h. Dose may be increased to a maximum of 0.1 mg/kg. (Meredith, 2015)
  • 0.05 mg/kg PO sid (Varga, 2013)
Formulations available:[1]
  • Oral: 2.5 mg, 5 mg, 20 mg tablets. Available in a compound preparation with spironolactone (Cardalis tablets) in the following formulations: 2.5 mg benazepril/20 mg spironolactone, 5 mg benazepril/40 mg spironolactone, 10 mg benazepril/80 mg spironolactone.

A angiotensin converting enzyme (ACE) inhibitor. For treatment of cardiac heart failure and cardiac renal failure.

Do not use in cases of cardiac output failure. Can be associated with an increase in azotaemia in rabbits.[1]

Betamethasone Fusiderm, Norbet, Otomax, Betnesol, Maxidex Corticosteroid
  • 0.1 mg/kg SC q24h (Meredith, 2015)
  • Otic: 4 drops of polypharmaceutical to affected ear q12h (Meredith, 2015)
  • Ocular: 1 drop of ophthalmic solution to affected eye q6–8h (Meredith, 2015)
  • Skin: Apply cream to affected area q8–12h (Meredith, 2015)
Formulations available:[1]
  • Injectable: 4 mg/ml solution for IV or IM use.
  • Oral: 0.25 mg tablet.
  • Topical: 0.1% cream with 0.5% fusidic acid. Betamethasone is also present in varying concentrations with or without antibacterials.
  • Ophthalmic/Otic: 0.1% solution; 0.88% mg/ml suspension with clotrimazole and gentamicin.

Used for short-term relief of inflammatory but non-infectious conditions. On a dose basis, 0.12 mg betamethasone is equivalent to 1 mg prednisolone.[1]

Use glucocorticosteroids with care in rabbits as they act as strong immunodepressants.[1][4] Wear gloves when applying cream. Topical corticosteroids should not be used on animals with ulcerative keratitis.[1]

Bethanecol Myotonine Muscarinic agonist
  • 2.5-5 mg/kg PO q12h. Titrate doses upwards to avoid adverse effects. (Meredith, 2015)
Formulations available:[1]
  • Oral: 10 mg tablets.

Used to empty the bladder and increase urination by increasing urinary bladder detrusor muscle tone and contraction.

Best given on an empty stomach to avoid GI distress.[1]

Bismuth salts
(Bismuth carbonate)
Pepto-Bismol Gastic cytoprotectant
  • Pepto-Bismol: 0.3-0.6 ml/kg PO q4-6h (Meredith, 2015)
Formulations available:[1]
  • Oral: Pepto-Bismol: bismuth subsalicylate suspension.

Used for acute oral poisoning, gastric ulceration, and flatulent diarrhea. Doses are empirical.[1]

Do not use where specific oral antidotes are being administered in cases of poisoning. Do not use if the animal is unconscious, fitting, or has a reduced cough reflex. In patients with an intestinal obstruction, do not use when enterotomy or enterectomy is to be performed.[1]

Avoid long-term use as absorbed bismuth is neurotoxic.[1]

Bromhexine Bisolvon Mucolytic
  • 0.3 mg/animal PO q24h or via nebulizer as 0.15 mg/ml for 20-30 minutes, 1-3 times daily (Meredith, 2015)
  • 0.3 mg PO sid; anecdotally may be used more frequently (Varga, 2013)
Formulations available:[1]
  • Injectable: 3 mg/ml solution.
  • Oral: 10 mg/g powder.

Used to manage respiratory diseases.

Bupivacaine Marcain, Sensorcaine Analgesic
  • 1 mg/kg local infusion, do not exceed 2 mg/kg (Meredith, 2015)
Formulations available:[1]
  • Injectable: 2.5, 5.0, 7.5 mg/ml solutions. 5.0 mg/ml solution with 1:200,000 adrenaline.

Do not give IV or use for IV regional anesthesia as it may precipitate severe cardiac arrhythmias.[1]

Buprenorphine Buprecare, Buprenodale, Vetergesic Analgesic
  • 0.03-0.06 mg/kg SC/IM/IV q6-12h (Meredith, 2015)
  • 0.03 mg/kg SC bid (Varga, 2013)
  • 0.01-0.05 mg/kg q8-12h; SC/IM/IV (Blackwells, 2011)
  • 0.01-0.05 mg/kg SC/IM/IV q6-12h (Ramsey, 2011)
  • 0.02-0.1 mg/kg BW IV/SC q12h (Carpenter, et al., 1995)
  • 0.01-0.05 mg/kg BW SC/IV q6-12h (Flecknell, 1991)
  • 0.02-0.05 mg/kg BW SC/IM/N q8-12h (Flecknell, 1985; Jenkins, 1987)
Formulations available:[1]
  • Injectable: 0.3 mg/ml solution; available in 1 ml vials that do not contain a preservative, or in 10 ml multidose bottle that contains chlorocresol as preservative.

Provides analgesia without marked sedation. Used for relief of mild to moderate perioperative pain. It is less potent but longer acting than fentanyl/fluanisone.[3]:321

Doses less than 0.03 mg/kg have very limited analgesic effects but still have some sedative effects.[1]

Buserelin Receptal Fertility drug
  • 0.2 mL/rabbit (Varga, 2013)
Formulations available:[1]
  • Injectable: 4 µg/ml solution.

Buserelin is a synthetic GnRH (gonadotrophin releasing hormone) analogue that stimulates LH and FSH production, thus causing oestrus to develop and progress.[1]

Used to supplement natural LH in cases of ovulation failure or delay and induce lactation postpartum in mammals.[1] In rabbits, it is used to induce ovulation postpartum for insemination and to improve conception rates.[1]

Pregnant women should not administer the product. Anaphylactic reactions may occasionally occur.[1]

Butorphanol Alvegesic, Dolorex, Torbugesic, Torbutrol, Torphasol Analgesic
  • 0.1-0.5 mg/kg SC q4h (Meredith, 2015)
  • 0.1-0.5 mg/kg SQ/IM/IV q4-6h (Blackwells, 2011)
  • 0.1-0.5 mg/kg SC q4h (Ramsey, 2011)
  • 0.1-0.5 mg/kg BW IM/IV/SC q4h (Carpenter, et al., 1995)
  • 0.1-0.5 mg/kg BW IV q4h (Flecknell, 1989)
Formulations available:[1]
  • Injectable: 10 mg/ml solution.
  • Oral: 5 mg, 10 mg tablets.

Used for management of mild perioperative pain. Can cause sedation in combination with other drugs.

Protect from light.

Buscopan Analgesic,
  • 0.1 ml/kg IV/IM q12h (Meredith, 2015)
Formulations available:[1]
  • Injectable: 4 mg/ml butylscopolamine + 500 mg/ml metamizole in 100 ml multidose bottle

Used to control gastrointestinal pain associated with urinary obstruction in rabbits.

Should not be used in animals with intestinal obstruction or gastrointestinal ileus.

Calcium EDTA
  • Chelation, lead toxicosis: 25 mg/kg q24h to q6h for 5 days; SC; dilute to 10 mg/mL with sale. Repeat if necessary. (Blackwells, 2011)
Carbaryl 5% powder
  • Ectoparasites: Dust lightly once weekly. (Blackwells, 2011)
Carbomer 980 Lubrithal Mucinomimetic
  • 1 drop per eye q4-6h (Meredith, 2015)
Formulations available:[1]
  • Ophthalmic: 0.2% (10 g tube, single-use vial), 0.25% (10 g tube) gel. This formulation is marketed specifically for small animals. Other formulations are widely available for general sale.

Used for tear replacement and tear film disorders.

Carprofen Activyl, Bonocarp, Canidryl, Carprieve, Carprodyl, Carprogesic, Dolagis, Norocarp, Norodyl, Rimadyl, Rimifin Analgesic
  • 2-4 mg/kg SC q24h or 1.5 mg/kg PO q24h (Meredith, 2015)
  • 2-4 mg/kg SC sid, 1.5 mg/kg PO bid (Varga, 2013)
  • 1-5 mg/kg PO q12h or 2-4 mg/kg SC, IV q24h (Blackwells, 2011)
  • 2-4 mg/kg SC q24h (Ramsey, 2011)
  • 1.5 mg/kg PO (Ramsey, 2011)
  • 1.5 mg/kg BW PO bid (Flecknell, 1996)
Formulations available:[1]
  • Injectable: 50 mg/ml.
  • Oral: 20 mg, 50 mg, 100 mg tablets.

A NSAID used to control postoperative pain and inflammation following surgery and to reduce chronic inflammation.

Should not be given to dehydrated, hypovolaemic or hypotensive patients or those with GI disease or blood clotting abnormalities. Use with care for animals with renal disease. Do not give to pregnant animals or animals less than 6 weeks old.[1]

Cefaseptin, Cephacare, Ceporex, Rilexine, Therios Antibiotic
  • 15-20 mg/kg SC q12-24h (Meredith, 2015)
  • 15 mg/kg SC bid, 20 mg/kg SC sid (Varga, 2013)
  • 15 mg/kg q12h; IM; DO NOT administer orally (Blackwells, 2011)
Formulations available:[1]
  • Injectable: 180 mg/ml (18%) suspension.

Active against several Gram-positive and Gram-negative organisms (e.g. Staphylococcus, Pasteurella and Escherichia coli). Pseudomonas and Proteus are often resistant.[1][3]

Risk of dysbiosis and fatal enterotoxaemia if given orally.[3] Injection of cephalosporin has proven safe.[2]

  • Local treatment in abscess cavities: 2 g/20 g PMMA (Blackwells, 2011)
Cefotaxime Cefotaxime Antibiotic
  • 50 mg/kg IM/IV q8h (Meredith, 2015)
Formulations available:[1]
  • Injectable: 500 mg, 1 g, 2 g powders for reconstitution.

A 3rd generation cephalosporin with good activity against many Gram-negative organisms, especially Enterobacteriaceae (not Pseudomonas) but lower activity against many Gram-positive organisms than 1st and 2nd generation cephalosporins.[1]

The reconstituted solution is stable for 10 days when refrigerated.[1]

May produce pain on injection; GI disturbance and superinfection with resistant microorganisms is a potential risk. Use with care in patients with renal disease.[1]

Ceftazidime Fortum, Kefadim Antibiotic
  • 100 mg/kg IM q12h (Meredith, 2015)
  • 50 mg/kg IM/IV tid; literature cites half-life not dosing frequency; this dose effective anecdotally. (Varga, 2013)
Formulations available:[1]
  • Injectable: 500 mg, 1 g, 2 g, 3 g powders for reconstitution.

A 3rd generation cephalosporin with higher activity against many Gram-negative organisms but lower activity against many Gram-positives when compared to 1st and 2nd generation cephalosporins.[1]

May produce pain on injection.

  • Local treatment in abscess cavities: 2 g lyophilized drug/20 g PMMA (Blackwells, 2011)
Celecoxib NSAID
  • 68 mg/kg PO bid; experimental dosage used for adhesion prevention and much higher than doses reported in other species like birds (Varga, 2013)
Cholestyramine Questran Ion exchange resin
  • Enterotoxaemia: 0.5 g/kg PO bid or sid, 2 g/20 mL water bid or sid; can be used prophylactically (Varga, 2013)
Chloramphenicol Chloramphenicol, Chloromycetin Ophthalmic Ointment, Chloromycetin Redidrops, Kemicetine Antibiotic
  • 50 mg/kg PO/SC q12-24h (Meredith, 2015)
Formulations available:[1]
  • Injectable: 1 g powder for reconstitution.
  • Topical: Ophthalmic 1% ointment; 0.5% solution.
  • Oral: 250 mg capsules.

Used against Gram-positive (e.g. Streptococcus, Staphylococcus), Gram-negative (e.g. Brucella, Salmonella, Haemophilus) and obligate anaerobic bacteria (e.g. Clostridium, Bacteroides fragilis). Other sensitive organisms include Chlamydophila, Mycoplasma (unreliable in treatment of ocular mycoplasmosis) and Rickettsia. Resistant organisms include Nocardia and Mycobacterium. Acquired resistance may occur in Enterobacteriaceae.[1]

Chloramphenicol palmitate Antibiotic
  • General antibiotic therapy: 50 mg/kg q12h to q8h; IM, SC (Blackwells, 2011)
Chloramphenicol succinate Antibiotic
  • General antibiotic therapy: 30-50 mg/kg q12h to q8h; IM, SC (Blackwells, 2011)
Chloralose Anesthetic
  • 80-100 mg/kg BW IV of 1% solution (Green, 1982)
Chlorhexidine Hibiscrub, Savlon, Chlorohex, CLX wipes, Otodine, TrizChlor, Viatop Antiseptic
  • Apply to affected area q8h at 0.5-2.0% concentrations. 0.05% solution in water can be used as a safe wound flush (Meredith, 2015)
  • Otic: Dilute optical products to a 1.0% concentration and apply topically q8-12h (Meredith, 2015)
Formulations available:[1]
  • Cleansing solution: 1.5% chlorhexidine + cetrimide (Savlon)
  • Surgical scrub solution: 4% chlorhexidine + isopropyl alcohol (Hibiscrub)
  • Mouthwash: 0.12% chlorhexidine (Chlorohex)
  • Topical gel: 0.06% chlorhexidine, aqua, raffinose, propylene glycol, saponins, triethanolamine, acrylates, phenoxyethanol, benzoic acid esters, allantoin (Viatop)
  • Topical skin cleaner: Chlorhexidine, Tris-EDTA, zinc gluconate, glycerine, climbazole, benzyl alcohol, propylene glycol (CLX wipes)
  • Ear cleaner: 0.15% chlorhexidine + EDTA (TrizChlor); Chlorhexidine, Tris-EDTA, lactic acid (Otodine).

Used for:[1]

  • Topical treatment of Malassezia infections (Microbex).
  • Washing surgical instruments, routine antisepsis for surgical operations (Savlon, Hibiscrub) and dental hygiene (Chlorohex).
  • Topical treatment of mild pruritus (Viatop).
  • Ear cleaners for cleansing and removal of cerumen.

Do not use in ears where integrity of the tympanum is unknown. Do not use on eyes. Ototoxic and may irritate mucous membranes.[1]

Piriton Antihistamine
  • 0.2-0.4 mg/kg PO q12h (Meredith, 2015)
Formulations available:[1]
  • Oral: 4 mg tablet, 0.4 mg/ml syrup.

Use to manage allergic disease and prevention as well as early treatment of anaphylaxis.[1]

Chlorphenamine maleate Antihistamine
  • 200-400 µg/kg PO bid (Varga, 2013)
Paediatric syrup available.
Chlorpromazine Sedative
  • 1-10 mg/kg BW IM (Carpenter, et al., 1995)
  • 25 mg/kg BW IM (Produces myositis; CCAC, 1984)
  • Absorption of clostridial enterotoxins: 2 g in 20 mL water once daily by gavage (2.5-3.8 kg animal) (Blackwells, 2011)
Chorionic gonadotrophin,
Human chorionic gonadotrophin (hCG)
Chorulon Fertility drug
  • 20-25 IU/rabbit IV once to induce ovulation
Formulations available:[1]
  • Injectable: 1500 IU powder for reconstitution.

Used to supplement or replace LH in cases of ovulation failure or delay, to induce lactation post-partum, or in females who fail to hold to mating.[1]

Reconstituted vials do not contain any preservative and should be discarded within 24 hours.[1]

Atopica, Optimmune, Neoral, Sandimmun Immunosuppressant
  • 5 mg/kg PO q24h for idiopathic sebaceous adenitis (Meredith, 2015)
Formulations available:[1]
  • Oral: 10 mg, 25 mg, 50 mg, 100 mg capsules; 100 mg/ml solution.

Used for sebaceous adenitis treatment in rabbits.

Cimetidine Zitac, Cimetidine, Dyspamet, Tagamet Antacid,
  • 5-10 mg/kg PO q6-8h (Meredith, 2015)
  • 5-10 mg/kg PO/SC/IM/IV q12h to q8h (Blackwells, 2011)
Formulations available:[1]
  • Injectable: 100 mg/ml solution in 2 ml ampoule.
  • Oral: 100 mg, 200 mg, 400 mg, 800 mg tablets; 40 mg/ml syrup.

Used as a gastric protectant.

Ciprofloxacin Ciloxan, Ciproxin Antibiotic
  • 10-20 mg/kg PO q24h or 1 drop to affected eye q6h; loading dose can by used 1 drop to affected eye q15min for 4 doses (Meredith, 2015)
  • 5-20 mg/kg PO bid (Varga, 2013)
  • General antibiotic therapy: 10-20 mg/kg PO q12h. 15-20 mg/kg PO once daily to q8h. (Blackwells, 2011)
Formulations available:[1]
  • Oral: 100 mg, 250 mg and 500 mg tablets; 50 mg/ml suspension.
  • Ophthalmic: 0.3% solution in 5 ml bottle; 0.3% ointment in 3.5 g tube.

Used against a wide range of Gram-negative and some Gram-positive aerobes; some activity against Mycoplasma and Chlamydophila. Active against many ocular pathogens, including Staphylococcus and Pseudomonas aeruginosa, although there is increasing resistance amongst staphylococci and streptococci.[1]

Ocular form shown to maintain therapeutic levels in tear film for 6h.[3]

Cisapride Propulsid Prokinetic
  • 0.1-1.0 mg/kg (typically 0.5 mg/kg) PO q8-12h (Meredith, 2015)
  • 0.5 mg/kg PO bid (Varga, 2013)
  • Gastrointestinal promotility agent: 0.5 mg/kg q8-12h; PO, SC (Blackwells, 2011)
Formulations available:[1]
  • Various formulations (including tablets and suspensions) available as a veterinary special depending on requirements.

Very effective product in rabbits for GI stasis.[1][3] Unfortunately, the product has been withdrawn due to potentially fatal cardiac arrhythmias in humans but is solely available to the veterinary profession.[1]

Clarithromycin Klaricid Antibiotic
  • 80 mg/kg PO q12h with rifampin at 40 mg/kg PO q12h for Staphylococcus osteomyelitis (Meredith, 2015)
Formulations available:[1]
  • Oral: 250 mg, 500 mg tablets; 125 mg/5 ml suspension; 250 mg/5 ml suspension; 250 mg granules sachet (to be dissolved in water).

Active against Gram-positive cocci (some Staphylococcus spp. resistant), Gram-positive bacilli, some Gram-negative bacilli (e.g. Pasteurella) and some spirochaetes (e.g. Helicobacter). Some strains of Actinomyces, Nocardia, Chlamydophila, Mycoplasma and Rickettsia also inhibited. Most strains of Enterobacteriaceae (Pseudomonas, Escherichia coli, Klebsiella) are resistant.[1]

Used for respiratory tract infections, mild to moderate skin and soft tissue infections, and non-tubercular mycobacterial infections.[1]

Clindamycin Antibiotic DO NOT USE Only for local use in abscesses incorporated into AIPMMA beads; should not be used orally.[3]

Causes 50 to 100% fatal enteritis, dependent on dosage.[2]

Clotrimazole Antifungal
  • Topical application to clipped skin as needed (Blackwells, 2011)
Amoxycillin/Clavulanic acid
Clavabactin, Clavaseptin, Clavucil, Clavudale, Combisyn, Kesium, Nisamox, Noroclav, Synulox, Augmentin Antibiotic DO NOT USE
Questran Bile acid sequestrant
  • 2 g/rabbit PO syringed gently with 20 ml water q24h (Meredith, 2015)
Formulations available:[1]
  • Oral: 4 g powder/sachet

Use to absorb toxins produced in the GI tract following the development of overgrowth of Clostridium.[1]

May cause constipation.

Cyproheptadine Stimulant
  • Appetite stimulant: 1 mg/rabbit once daily to q12h; PO (Blackwells, 2011)
Dexamethasone Anti-inflammatory
  • 1-2 mg/kg IM, IV (Varga, 2013)
  • 0.5-2.0 mg/kg q12h; PO, SC, IM. Wean off dosage at end of treatment. (Blackwells, 2011)
Rarely indicated in rabbits. Use with caution due to likelihood of debilitating side effects.
Diazepam Diazemuls, Diazepam, Diazepam Rectubes, Valium Sedative
  • 1-2 mg/kg IV, IM (Varga, 2013)
  • Seizures: 1-2 mg/kg; IM, IV. 0.5-1.0 mg/kg IV for seizures; may repeat PRN up to 5 mg/kg total dose; may be administered rectally if IV access cannot be achieved (Blackwells, 2011)
  • Epileptic seizures: 1 mg/kg IV (Ramsey, 2011)
  • 2 mg/kg BW IV (Flecknell, 1987)
  • 4 mg/kg BW IM, IP (Flecknell, 1987)
  • 5-10 mg/kg BW IM (Harkness and Wagner, 1983)
  • 5-10 mg/kg BW IM, IP (Green, 1982)
Not analgesic
  • Management of congestive heart failure and cardiomyopathy: 0.005-0.01 mg/kg PO once daily to every other day (Blackwells, 2011)
Diltiazem Calcium channel blocker
  • 3.75-7.5 mg/kg IV, IM (Varga, 2013)
For use in adhesion prevention
Diphenhydramine Antihistamine
  • 2 mg/kg PO bid-tid (Blackwell, 2014)
  • 2 mg/kg q12h to q8h; PO, SC (Blackwells, 2011)
Used for torticollis
Domperidone Prokinetic
  • 0.5 mg/kg PO bid (Varga, 2013)
Similar action to metoclopramide with fewer side effects (Varga, 2013)
Doxapram Respiratory stimulant
  • 5 mg/kg IM, IV (Varga, 2013)
  • 2-5 mg/kg as needed; SC, IV (Blackwells, 2011)
Doxycycline Antibiotic
  • 2.5-4 mg/kg PO sid (Varga, 2013)
Enalapril ACE inhibitor
  • For treatment of CHF or CRF: 0.25-0.5 mg/kg PO sid or eod (Varga, 2013)
  • Management of congestive heart failure and cardiomyopathy: 0.25-0.5 mg/kg once daily to every other day; PO (Blackwells, 2011)
Enilconazole Antifungal
  • Apply topically as required. (Blackwells, 2011)
Enrofloxacin Baytril, Bayer Antibiotic
  • 5 mg/kg SC bid, 10 mg/kg SC sid, 5-10 mg/kg PO bid (Varga, 2013)
  • General antibiotic treatment: 5-20 mg/kg PO, SC, IM, IV q12-24h (Blackwells, 2011)
(Baytril Otic)
  • Topical otic antibiotic: Apply topically as directed, adjust dose to body size of patient (Blackwells, 2011)
Erythromycin Antibiotic DO NOT USE DO NOT USE

Causes diarrhea.[2]

Epoetin alpha
  • Stimulates erythropoiesis: 50-150 IU/kg every 2-3 days; SC (Blackwells, 2011)
  • Cardiac arrest: 0.2 mg/kg IV (Blackwells, 2011)
Estriol Hormone
  • 0.1 mg/rabbit PO sid; can titrate dose to effect; may notice estrogenic effects (Varga, 2013)
Fenbendazole Antihelmintic
  • 20 mg/kg PO (Varga, 2013)
  • 20 mg/kg once daily for 5-28 days; PO (Blackwells, 2011)
Treatment for E. cuniculi.
Fentanyl Durogesic, Fentanyl, Fentora, Sublimaze Analgesic
  • 25 µg patch for up to 72h (Foley et al., 2001)
Fentanyl-droperidol Innovar-Vet Sedative, Anesthetic
  • Anesthetic: 0.4 ml/kg BW SC (Gonzalez-Gil et al., 2003)
  • Anesthetic: 0.10-0.50 ml/kg BW IM (Green, 1982)
  • Sedative: 0.17 ml/kg BW IM (CCAC, 1984)
  • Sedative: 0.15-0.17 ml/kg BW IM (Lewis and Jennings, 1972)
Fentanyl-fluanisone Hypnorm, Janssen Premedication, Analgesic, Anesthetic
  • 0.2-0.3 mL/kg IM, SC (Varga, 2013)
  • 0.2-0.5 ml/kg IM (Ramsey, 2011)
  • 0.5 ml/kg BW IM (Jenkins, 1987)

Can be used in combination with midazolam or diazepam (0.5-2 mg/kg) (Varga, 2013)

Provides analgesia to treat abdominal pain that accompanies digestive disorders and gas distension of the viscera. Fentanyl/fluanisone is a good sedative to clean uneaten caecotrophs from the perineum.[3]:321

Fluid therapy
  • 10-20 mL/kg/h IV; 10-15 mL/kg SC; Warm before use(Varga, 2013)
Flunixin Banamine, Flunixamine, Citation, Equileve, Meflosyl Solution NSAID, Analgesic
  • Analgesia: 1.1 mg/kg SC bid (Varga, 2013)
  • Analgesia: 0.3-2.0 mg/kg once daily to q12h for no more than 3 days; PO, deep IM (Blackwells, 2011)
  • 1.1 mg/kg BW SC, IM, try q12h (Liles and Flecknell, 1992)
Care in hypotensive patients.
Furosemide Diuretic
  • 0.3-2 mg/kg IV, SC, IM (Varga, 2013)
  • 1-4 mg/kg q12h to q8h; IM IV. 1-2 mg/kg q12h to q8h; PO long-term use (Blackwells, 2011)
Indicated for treatment of CHF.
Fusidic acid: eye drops Fucithalmic, Leo
  • Conjunctivitis: 1 drop/eye sid or bid (Varga, 2013)
Fusidic acid ointment Fuciderm, Leo
  • Superficial pyoderma: Topical sid or bid (Varga, 2013)
Caution as contains steroids
Gentamicin Tiacil, Virbac
  • Conjunctivits: 1-2 drops/eye tid; give for 5-7 days (Varga, 2013)
  • Local treatment in abscess cavity: 1 g/20 g PMMA (Blackwells, 2011)
Glucose 5%
  • Anorexia, perioperatively: 10 mL/kg IV, SC; warm before use (Varga, 2013)
Glycopyrrolate Premedication
  • Premedication: 0.01 mg/kg IV, SC (Varga, 2013)
  • Organophosphate poisoning: 0.1 mg/kg IM (Varga, 2013)
  • Anticholinergic preanesthetic: 0.01-0.1 mg/kg; SC (Blackwells, 2011)
Does not cross blood-brain barrier and cause mydriasis.
Griseofulvin Antifungal
  • Ringworm: 25 mg/kg PO sid; continue for at least 2 weeks (Varga, 2013)
  • Systemic antifungal therapy: 25 mg/kg once daily or divided q12h for 28-40 days; PO (Blackwells, 2011)
Haloperidol Sedative
  • 0.2-0.4 mg/kg BW IM bid (Iglauer, et al., 1995)
  • Volume expansion: 20 mL/kg IV (Blackwells, 2011)
  • 0.1 mg/kg SC IM q2-4h (Blackwells, 2011)
Hydroxyzine Antihistamine
  • 2 mg/kg q12h to q8h; PO (Blackwells, 2011)
Ibuprofen Analgesic
  • 10-20 mg/kg BW IV, try q4h (Flecknell, 1991)
  • Fleas: 10 mg/kg topical (Varga, 2013)
  • Topical flea treatment: Treat as per cats (Blackwells, 2011)
Not effective against mites.
Indomethacin Analgesic
  • 12.5 mg/kg BW PO (Keller, et al., 1988)
Iron dextran
  • Iron deficient anemia: 4-6 mg/kg once; IM (Blackwells, 2011)
Isoflurane Anesthesic
  • Anesthetic of choice (Blackwells, 2011)
Itraconazole Antifungal
  • Systemic antifungal therapy: 5 mg/kg daily for 3-4 weeks (Blackwells, 2011)
  • Mites: 400 μg/kg SC; repeat after 10-14 days (Varga, 2014)
  • Ectoparasites: 200-400 μg/kg once, repeat in 10-14 days for a total of 2-3 treatments as needed; SC (Blackwells, 2011)
Ketamine Ketaset injection, Narketan-10, Vetalar-V Sedative, Anesthetic
  • Anesthesia: 10-20 mg/kg IM
  • 15-30 mg/kg IM, SC alone gives moderate to heavy sedation with some analgesia but may have long recovery at this high dose (Ramsey, 2011)
  • 25 mg/kg BW intranasally for light surgical anesthesia (Robertson and Eberhart, 1994)
  • Sedative: 30 mg/kg BW IM (Bauck, 1989)
  • Anesthetic: 50 mg/kg BW IM for immobilization (Flecknell, 1987)
  • Anesthetic: 44 mg/kg BW IM (Weisbroth and Fudens, 1972)
Ketamine +
  • 24-40 mg/kg + 0.25-1.0 mg/kg; IM (Blackwells, 2011)
Ketamine +
  • 15-20 mg/kg + 1-3 mg/kg; IM (Blackwells, 2011)
Ketamine +
  • 15-20 mg/kg + 0.5-1.0 mg/kg; IM (Blackwells, 2011)
Ketoconazole Antifungal
  • Systemic antifungal therapy: 10-15 mg/kg once daily for 3-4 weeks (Blackwells, 2011)
Ketoprofen Ketofen Analgesic
  • 1-3 mg/kg PO bid (Varga, 2013)
  • 1 mg/kg q24h to q12h; IM (Blackwells, 2011)
  • 1-3 mg/kg IM, SC q24h (Ramsey, 2011)
  • 3 mg/kg BW IM (Flecknell, 1996)
  • 1 mg/kg BW IM (Perrin et al., 1990)
Can be used to soften and lubricate caecal/intestinal contents. (Varga, 2013)
Lidocaine Antiarrhythmia
  • 1-2 mg/kg IV or 2-4 mg/kg IT (Blackwells, 2011)
Lime sulfur 2.5% solution
  • Ectoparasites: Apply once weekly for 4-6 weeks (Blackwells, 2011)
Lincomycin Antibiotic DO NOT USE DO NOT USE

Causes 33 to 100% fatal enteritis, dependent on dosage.[2]

Liquid paraffin
  • 1-2 mL/kg bid (Varga, 2013)

Softens impacted gastric or caecal contents. Administer with care (preferably mixed with food) as is easily aspirated.[3]

Lufenuron Flea treatment
  • Treat as per cat; 30 mg/kg PO every 30 days (Blackwells, 2011)
Marbofloxacin Antibiotic
  • 2-5 mg/kg PO/SC sid (Varga, 2013)
  • 5 mg/kg PO q24h (Blackwells, 2011)
Has been used at 10 mg/kg sid for pasteurellosis. (Varga, 2013)
Meclizine Antiemetic
  • Torticollis: 2-12 mg/kg PO sid-tid (Varga, 2013)
  • Vestibular disorders: 2-12 mg/kg q8-12h; PO (Blackwells, 2011)
Medetomidine Domitor, Dorbene, Dormilan, Medetor, Sedastart, Sedator, Sededorm Sedative
  • Premedication: 80-100 μg IM, SC in combination with an opioid and ketamine. (Ramsey, 2011)
  • 100-500 μg/kg BW IM, SC (Flecknell, 1996)
  • 300-500 μg/kg BW SC (Aeschbacher, 1995)
  • 250 μg/kg BW IM (Ko, et al., 1992)
Melatonin Hormone
  • 1-2 mg PO sid; dose extrapologated from other species, not yet validated (Varga, 2013)
Meloxicam Metacam Analgesic
  • 0.3-0.6 mg/kg PO/SC sid-bid (Varga, 2013)
  • 0.2-0.3 mg/kg SC, IM q24h or 0.2-0.5 mg/kg PO q12-24h (Blackwells, 2011)
Can be used up to 1.5 mg/kg without accumulation (Varga, 2013)
Demerol, Meperidine, Pethidine Analgesic
  • 5-10 mg/kg IM, SC (Ramsey, 2011)
  • 10-20 mg/kg BW SC, IM q2-3h (Flecknell, 1991)
  • 10 mg/kg BW SC, IM q2-3h (Jenkins, 1987)
Metaclopramide Prokinetic
  • 0.5 mg/kg SC bid (Varga, 2013)
Stimulates gastric emptying and GI motility.[3]:321
  • 10 mg/kg BW N (Flecknell, 1987)
Metoclopramide Reglan Prokinetic
  • 0.5 mg/kg SC, PO bid (Varga, 2013)
  • Gastrointestinal promotility agent: 0.2-1.0 mg/kg PO, SC, IM q12h or 1-2 mg/kg/day IV as a constant rate infusion (Blackwells, 2011)
May not be effective in young rabbits. (Varga, 2013)
Metronidazole Antibacterial
  • 20 mg/kg PO bid (Varga, 2013)
  • For anaerobic infections: 20mg/kg PO IV q12h. Treat for 2 weeks for Clostridium spp. (Blackwells, 2011)
Treatment of choice for enterotoxaemia. (Varga, 2013)
Miconazole (cream or 2% shampoo) Antifungal
  • Topical antifungal: Apply topically as required (Blackwells, 2011)
Midazolam Hypnovel Sedative
  • 0.5-2 mg/kg; IM (Blackwells, 2011)
  • 0.2-2 mg/kg IV, IM (Ramsey, 2011)
  • general anaesthesia: 0.2 mg/kg IV when used with Fentanyl/Fluanisone (q.v.) (Ramsey, 2011)
  • 0.5-2 mg/kg BW IM, IP, IV (Flecknell, 1996)
  • 2 mg/kg BW IN (Robertson and Eberhart, 1994)
  • 4 mg/kg BW IM, IP (Flecknell, 1987)
  • 2 mg/kg BW IV (Flecknell, 1987)
Minocycline Antibiotic DO NOT USE DO NOT USE

Causes reduction of growth rate.[2]

Morphine Duramorph, Morphine, Oramorph Analgesic
  • 2-5 mg/kg q2-4h; IM, SC (Blackwells, 2011)
  • 2-5 mg/kg IM, SC q2-4h (Ramsey, 2011)
  • 2-5 mg/kg BW SC, IM q24h (Flecknell, 1991)
  • 5 mg/kg BW SC, IM q2-4h (Flecknell, 1985; Jenkins, 1987)
Moxidectin Antiparasitic
  • 0.2 mg/kg PO; repeat in 10 days (Varga, 2013)
Nalbuphine Nubain Analgesic
  • 1-2 mg/kg IV, IM q4-5h (Ramsey, 2011)
  • 1 mg/kg BW IP, SC (Flecknell, 1996)
  • 0.1 mg/kg BW IV (Flecknell, 1996)
  • 1-2 mg/kg BW IV q4-5h (Flecknell, 1989)
Naloxone (titrate to effect)
  • Opoid reversal by titration: 0.01-0.1 mg/kg; IM, IV (Blackwells, 2011)
Nandrolone Steroid
  • 2 mg/kg SC, IM (Varga, 2013)
Nimesulide NSAID
  • 0.5 mg/rabbit IM/IP sid × 5 days (Varga, 2013)

For use in prevention of adhesions

Orbifloxacin Antibiotic
  • 5-20 mg/kg PO sid; doses anecdotal(Varga, 2013)
Oxybendazole Antiprotozoal
  • To treat E. cuniculi: 20 mg/kg once daily for 7-14 days; PO; then reduce to 15 mg/kg once daily for 30-60 days (Blackwells, 2011)
Oxymorphone Analgesic
  • 0.05-0.2 mg/kg q12h to q8h; SC, IM (Blackwells, 2011)
  • 0.1-0.2 mg/kg BW IM, IV (Cantwell, 2001)
Oxytetracycline Antibiotic
  • 15 mg/kg SC, IM side every 3 days; 30 mg/kg (depot SC; 1 mg/kL DW; 50 mg/kg PO (Varga, 2013)
Oxytocin Hormone
  • Stimulation of uterine contraction in non-obstructive dystocia: 1-2 IU/kg SC, IM (Varga, 2013)
  • To stimulate uterine motility or milk letdown: 0.1-3 U/kg; SC, IM (Blackwells, 2011)
Paracetamol Analgesic
  • 200-500 mg/kg PO bid (Varga, 2013)
Mild analgesic.

Can be used in tandem with NSAIDs

Penicillin Procaine Antibiotic
  • 40,000 IU/kg (40 mg/kg) SC sid (Varga, 2013)
  • 40-60,000 IU/kg SQ q48h (Blackwells, 2011)
Causes acute and/or chronic enteritis (diarrhea) after oral administration. Injection of cephalosporin has proven safe.[2]

Contain 1000 IU/mg 5-day course for Treponema paraliuscuniculi. (Varga, 2013)

Penicillin G, benzathine Antibiotic
  • Treponema paraliuscuniculi treatment: 20 mg/kg PP + 15 mg BP/kg SC weekly; give 3 weekly injections (Varga, 2013)
  • General antibiotic treatment: 42,000-84,000 IU/kg SC q24h (Blackwells, 2011)
Do not administer orally.
Penicillin G, procaine Antibiotic
  • 20 mg/kg PP + 15 mg BP/kg SC weekly; give 3 weekly injections (Varga, 2013)
  • 42,000-60,000 IU/kg SC q48h treatments; SC, IM (Blackwells, 2011)
Treatment for Treponema cuniculi.
Penicillamine Chelating agent
  • 30 mg/kg PO bid (Varga, 2013)
For copper and lead toxicity.
Pentazocine Pentazocine, Talwin Analgesic
  • 5 mg/kg BW IV q24h (Flecknell, 1991)
  • 10-20 mg/kg BW SC, IM q4h (Flecknell, 1985; Jenkins, 1987)
  • 15-30 mg/kg PO bid; doses reported from experimental data in literature (Varga, 2013)
Demerol, Meperidine, Pethidine Analgesic
  • 5-10 mg/kg IM, SC (Ramsey, 2011)
  • 10 mg/kg BW SC, IM q2-3h (Flecknell, 1987)
  • Increase urethral outflow resistance: 5-10 mg/rabbit PO bid (Varga, 2013)
For use in urinay incontinence.
  • Positive inotrope and vasodilator: 0.25-0.3 mg/kg PO bid; drug doses anecdotal (Varga, 2013)
  • 0.1-0.3 mg/kg PO q12h-24h (Blackwells, 2011)
Piperazine adipate Antiparasitic
  • 500 mg/kg once daily for 2 days; PO (Blackwells, 2011)
Piroxicam Brexidol, Feldene, Piroxicam Analgesic
  • 0.3 mg/kg BW PO q48h (Flechell, 1996)
Polysulfate glycosaminoglycans
  • Nutraceutical treatment for joint inflammation: 2.2 mg/kg q3d for 21-28 days, then q14d; SC, IM (Blackwells, 2011)
  • 20-50 mg/kg PO q24h x 30 days (Blackwells, 2011)
Praziquantel Antiparasitic
  • For treatment of cestodes: 6 mg/kg SC; repeat after 10 days (Varga, 2013)
  • 5-10 mg/kg once, repeat in 10 days; PO, SC, IM (Blackwells, 2011)
Prednisone Anti-inflammatory
  • 0.5-2 mg/kg PO, IM, SC (Varga, 2013)
  • 0.5-2 mg/kg; PO (Blackwells, 2011)
Few indications in rabbits; use with extreme caution.
Prochloperazine Doses as high as 30 mg/kg tid are used to treat labyrinthine disorders in humans. (Varga, 2013)
Propofol Anesthetic
  • 2-6 mg/kg; IV slowly (Blackwells, 2011)
Pyrethrin products Antiparasitic DO NOT USE DO NOT USE
  • Gastric ulceration: 2 mg/kg IV sid, 2-5 mg/kg PO bid (Varga, 2013)
  • 2-5 mg/kg PO q12-24h or 2mg/kg SC, IV q24h (Blackwells, 2011)
Ranitidine Hcl
  • H2-receptor blocking agent for gastric ulcer therapy: 2 mg/kg once daily IV or 2-5 mg/kg twice daily PO (Blackwells, 2011)
Selamectin Antiparasitic
  • Mites: 6-18 mg/kg topical once only (Varga, 2013)
  • Treatment of ectoparasites and endoparasites: Treat as per cat; 6-10 mg/kg applied topically every 30 days (Blackwells, 2011)
Sevoflurane Anesthesic
  • Inhalant anesthetic used to effect (Blackwells, 2011)
  • Alleviation of gastrointestinal gas: 65-130 mg/animal q1h as needed; PO (Blackwells, 2011)
Sodium bicarbonate
  • Treatment of acidosis: 2 mEq/kg IV, IP (Blackwells, 2011)
Sodium calcium edetate
  • Lead poisoning: 27.5 mg/kg SC qid or 13 mg/kg SC, IV qid for 5 days then every 2-3 days if necessary; based on successful treatment of two cases. General dose rate for cattle, dogs, and cats. Preparation should be diluted 1:4 in 5% glucose or 0.9% saline prior to use. (Varga, 2013)
Spectinomycin Antibiotic DO NOT USE DO NOT USE

Causes diarrhea.[2]

Spiramycin Antibiotic DO NOT USE DO NOT USE

Causes nervousness.[2]

Stanozolol Steroid
  • Anabolic steroid: 1-2 mg/rabbit; PO, once (Blackwells, 2011)
  • Treatment of gastric ulceration and gastritis: 25 mg/kg q12h to q8h; PO (Blackwells, 2011)
  • Treatment of gastrointestinal coccidiosis: 25-50 mg/kg once daily, or 50 mg/kg loading dose followed by 25 mg/kg for 9 days; PO (Blackwells, 2011)
  • Coccidiosis: 100-233 mg/L DW (Varga, 2013)
Theophylline Bronchodilator
  • 10-20 mg/kg PO bid-tid; doses extrapolated from rodents. (Varga, 2013)
Has dose-dependent effects on the rabbit gastrointestinal tract. (Varga, 2013)
Tiletamine-zolazepam DO NOT USE DO NOT USE
Tilmicosin Antibiotic DO NOT USE DO NOT USE

Fatal adverse reaction has been observed. The reaction seems rabbit dependent and it is advised to do a test dose of 5 mg/kg before doubling dosage.[2]

Trimethoprim sulfadiazine/ sulphadiazine Antibiotic
  • 30 mg/kg PO bid, 48 mg/kg SC (Varga, 2013)
  • General antibiotic therapy: 30 mg/kg q12h; SC, PO (Blackwells, 2011)
Trimethoprim/ sulfamethoxazole Antibiotic
  • Coccidiosis: 40 mg/kg PO bid; continue for 7 days (Varga, 2013)
'Co-trimoxazole' human formulation available as paediatric syrup.
Tropicamide 1% eye drops
  • Mydriasis: Topically to dilate eyes in albino animals (Blackwells, 2011)
  • Coccidiosis: 25 ppm DW (Varga, 2013)
Can be used for treatment of rabbit colonies.
Tylosin Antibiotic DO NOT USE
  • 10 mg/kg SC, IM bid (Varga, 2013)

Causes diarrhea.[2]

Vancomycin Antibiotic DO NOT USE DO NOT USE

Causes acute toxicity with 100% mortality.[2]

  • 200 µg/kg SC tid × 9 doses; start immediately post-op then eight hourly for nine doses (Varga, 2013)
  • 200 µg/kg at surgery and q8h for 9 does total; IV, IP (Blackwells, 2011)
Prevent post-surgical adhesions.
Vitamin B complex
  • Thiamine deficiency: Dose to thiamine content at 1-2 mg/kg as needed; IM (Blackwells, 2011)
Vitamin K1
  • Treatment of anticoagulant rodenticide toxicosis: 2.5 mg/kg once daily; PO for 10-30 days 2-10 mg/kg as needed; IM (Blackwells, 2011)
Use with caution, anaphylaxis reported.
Xylazine Chanazine, Rompun, Sedaxylan, Virbaxyl, Xylacare, Xylapan Analgesic
  • 2-5 mg/kg IM, SC (Ramsey, 2011)
  • 1-5 mg/kg BW IM, SC (Arnemo, et al. 2002)
  • 1-3 mg/kg BW IM (Flecknell, 1987)
  • 3-5 mg/kg BW IM (Harkness and Wagner, 1983)
  • 5 mg/kg BW IM (Hughes, 1981)

Hawk, C, et al. (2005). Formulary for laboratory animals. (3rd ed.).
Meredith, A. (2015). BSAVA small animal formulary. (9th ed.).
Oglesbee, B. (2011). Blackwell's five-minute veterinary consult: Small mammal. (2nd ed.).
Ramsey, I. (2011). BSAVA small animal formulary. (7th ed.).
Varga, M. (2013). Textbook of rabbit medicine. (2nd ed.).

Further reading

See also